Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

Apoptosis and autophagic cell deaths are programmed cell deaths and they play essential
roles in cell survival, growth and development and tumorigenesis. The huge increase of …

Purpose Over the past few years, more and more new selective molecules directed against
specific cellular targets have become available for cancer therapy, leading to impressive …

Temozolomide (TMZ) was first known to be useful as a radiosensitiser in both primary brain
tumours like glioblastoma multiforme and oligodendroglioma. Later, TMZ proved its efficacy …

Background: Temozolomide (TMZ) has demonstrated clinical antitumor activity. In the US
and the EU, TMZ is licensed for the treatment of glioblastoma multiforme concurrently with …

Metronomic chemotherapy (MCT) is defined as the rhythmic chemotherapy of low‑dose
cytotoxic drugs with short or no drug‑free breaks over prolonged periods. MCT affects tumor …

Brain metastases are a frequent complication in patients with lung cancer and a significant
cause of morbidity and mortality. The prognosis of these patients is poor. Medical therapies …

BACKGROUND AND PURPOSE: This randomised phase II study evaluated the use of
Temozolomide (TMZ) concomitant with 30Gray (Gy) of Whole-brain irradiation (WBI) for …

Purpose Temozolomide dry powder formulations for inhalation, performed with no excipient
or with a lipid or lactose coating, have been evaluated. Methods The particle size of raw …