Where is nano today and where is it headed? A review of nanomedicine and the dilemma of nanotoxicology

C Domingues, A Santos, C Alvarez-Lorenzo… - ACS …, 2022 - ACS Publications
Worldwide nanotechnology development and application have fueled many scientific
advances, but technophilic expectations and technophobic demands must be …

Clinical translation of nanomedicines: Challenges, opportunities, and keys

MA Younis, HM Tawfeek, AAH Abdellatif… - Advanced drug delivery …, 2022 - Elsevier
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …

Multiple stimuli‐responsive MXene‐based hydrogel as intelligent drug delivery carriers for deep chronic wound healing

X Yang, C Zhang, D Deng, Y Gu, H Wang, Q Zhong - Small, 2022 - Wiley Online Library
Chronic wound healing is an important and basic issue in medical and healthcare fields.
Recently, stimuli‐responsive hydrogel systems have emerged as promising drug delivery …

Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Polymeric particle-based therapies for acute inflammatory diseases

ER Brannon, MV Guevara, NJ Pacifici, JK Lee… - Nature Reviews …, 2022 - nature.com
Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

Hierarchical microparticles delivering oxaliplatin and NLG919 nanoprodrugs for local chemo-immunotherapy

Q Zhang, G Kuang, Y Yu, X Ding, H Ren… - … Applied Materials & …, 2022 - ACS Publications
Chemo-immunotherapy shows promising antitumor therapeutic outcomes for many primary
cancers. Research in this area has been focusing on developing an ideal formula that …

Osteoimmunomodulatory nanoparticles for bone regeneration

J Wen, D Cai, W Gao, R He, Y Li, Y Zhou, T Klein… - Nanomaterials, 2023 - mdpi.com
Treatment of large bone fractures remains a challenge for orthopedists. Bone regeneration
is a complex process that includes skeletal cells such as osteoblasts, osteoclasts, and …

Prebiotics and postbiotics synergistic delivery microcapsules from microfluidics for treating colitis

K Yang, X Wang, R Huang, H Wang, P Lan… - Advanced …, 2022 - Wiley Online Library
Manipulation of gut microbiota by bacterial metabolites has shown protective effects against
colitis; while the efficacy is strictly limited by the poor oral delivery efficiency and single drug …

Cancer stem cells and the tumor microenvironment: targeting the critical crosstalk through nanocarrier systems

A Nayak, NM Warrier, P Kumar - Stem cell reviews and reports, 2022 - Springer
The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …