Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design
NA Meanwell - Journal of medicinal chemistry, 2018 - ACS Publications
The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …
versatility as a bioisostere and it has found application as a substitute for lone pairs of …
Introduction of fluorine and fluorine‐containing functional groups
T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …
were enabled most prominently by organo‐and transition‐metal catalysis. The most …
Applications of bioisosteres in the design of biologically active compounds
NA Meanwell - Journal of Agricultural and Food Chemistry, 2023 - ACS Publications
The design of bioisosteres represents a creative and productive approach to improve a
molecule, including by enhancing potency, addressing pharmacokinetic challenges …
molecule, including by enhancing potency, addressing pharmacokinetic challenges …
Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation
C Crowe, S Molyneux, SV Sharma, Y Zhang… - Chemical Society …, 2021 - pubs.rsc.org
The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …
Human pharmaceuticals in the aquatic environment: a challenge to green chemistry
SK Khetan, TJ Collins - Chemical reviews, 2007 - ACS Publications
One goal of this review is to bring out that the chemical enterprise needs to work to reduce
society's uncertainties with respect to the safety of persistent or pseudopersistent …
society's uncertainties with respect to the safety of persistent or pseudopersistent …
Fluorine in the environment, a review of its sources and geochemistry
R Fuge - Applied Geochemistry, 2019 - Elsevier
While F is an essential constituent of some rock-forming minerals such as fluorite and
apatite, its major occurrence in the lithosphere is within hydroxysilicate minerals where F …
apatite, its major occurrence in the lithosphere is within hydroxysilicate minerals where F …
Einführung von Fluor und fluorhaltigen funktionellen Gruppen
T Liang, CN Neumann, T Ritter - Angewandte Chemie, 2013 - Wiley Online Library
Die wichtigsten konzeptionellen Fortschritt auf dem Gebiet der Fluorierungen der letzten
zehn Jahre wurden durch die Organo‐und Übergangsmetallkatalyse ermöglicht. Die …
zehn Jahre wurden durch die Organo‐und Übergangsmetallkatalyse ermöglicht. Die …
The unique role of halogen substituents in the design of modern agrochemicals
P Jeschke - Pest Management Science: formerly Pesticide …, 2010 - Wiley Online Library
The past 30 years have witnessed a period of significant expansion in the use of
halogenated compounds in the field of agrochemical research and development. The …
halogenated compounds in the field of agrochemical research and development. The …
A General Synthesis of Fluoroalkylated Alkenes by Palladium‐Catalyzed Heck‐Type Reaction of Fluoroalkyl Bromides
An efficient palladium‐catalyzed Heck‐type reaction of fluoroalkyl halides, including
perfluoroalkyl bromides, trifluoromethyl iodides, and difluoroalkyl bromides, has been …
perfluoroalkyl bromides, trifluoromethyl iodides, and difluoroalkyl bromides, has been …
Revisiting pesticide pollution: The case of fluorinated pesticides
DAM Alexandrino, CMR Almeida, AP Mucha… - Environmental …, 2022 - Elsevier
Fluorinated pesticides acquired a significant market share in the agrochemical sector due to
the surge of new fluoroorganic ingredients approved in the last two decades. This growing …
the surge of new fluoroorganic ingredients approved in the last two decades. This growing …