The Multifaceted Role of Osteopontin in Prostate Pathologies

SV Silver, P Popovics - Biomedicines, 2023 - mdpi.com
The prostate gland, located beneath the bladder and surrounding the proximal urethra in
men, plays a vital role in reproductive physiology and sexual health. Despite its importance …

Novel mRNA adjuvant ImmunER enhances prostate cancer tumor-associated antigen mRNA therapy via augmenting T cell activity

Z Xu, ZX Xiao, J Wang, HW Qiu, F Cao… - …, 2024 - Taylor & Francis
Prostate cancer (PCa) is characterized as a “cold tumor” with limited immune responses,
rendering the tumor resistant to immune checkpoint inhibitors (ICI). Therapeutic messenger …

Development of a comprehensive gene signature linking hypoxia, glycolysis, lactylation, and metabolomic insights in gastric cancer through the integration of bulk and …

X Zhang, Y Li, Y Chen - Biomedicines, 2023 - mdpi.com
Background: Hypoxia and anaerobic glycolysis are cancer hallmarks and sources of the
metabolite lactate. Intriguingly, lactate-induced protein lactylation is considered a novel …

Epigenomics, Transcriptomics, and Translational Control in Prostate Cancer

G Kocic - Prostate Cancer: Advancements in the Pathogenesis …, 2024 - Springer
Epigenetics refers to changes in gene expression that are not caused by changes in the
underlying DNA sequence. It is now clear that epigenetic changes may play a significant …

[HTML][HTML] ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

W Feng, E Ladewig, N Salsabeel, H Zhao, YS Lee… - bioRxiv, 2023 - ncbi.nlm.nih.gov
To gain insight into how ERG translocations cause prostate cancer, we performed single cell
transcriptional profiling of an autochthonous mouse model at an early stage of disease …

The 29th Annual Prostate Cancer Foundation Scientific Retreat Report

AK Miyahira, HR Soule - The Prostate, 2024 - Wiley Online Library
Abstract Background The 29th Annual Prostate Cancer Foundation (PCF) Scientific Retreat
was held from October 27 to 29, 2022, at the Omni La Costa Resort in Carlsbad, CA. This …