Fungal morphogenesis

X Lin, JA Alspaugh, H Liu… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Morphogenesis in fungi is often induced by extracellular factors and executed by fungal
genetic factors. Cell surface changes and alterations of the microenvironment often …

[HTML][HTML] Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal

DJ Springer, RB Billmyre, EE Filler, K Voelz… - PLoS …, 2014 - journals.plos.org
Ongoing Cryptococcus gattii outbreaks in the Western United States and Canada illustrate
the impact of environmental reservoirs and both clonal and recombining propagation in …

Vaccination with a ZNF2oe Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts

T Pham, Y Li, W Watford, X Lin - Infection and Immunity, 2023 - Am Soc Microbiol
Systemic cryptococcosis is fatal without treatment. Even with the current antifungal therapies,
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …

Similar evolutionary trajectories in an environmental Cryptococcus neoformans isolate after human and murine infection

P Sephton-Clark, SA McConnell… - Proceedings of the …, 2023 - National Acad Sciences
A pet cockatoo was the suspected source of Cryptococcus neoformans recovered from an
immunocompromised patient with cryptococcosis based on molecular analyses available in …

Mutators enhance adaptive micro-evolution in pathogenic microbes

KJ Boyce - Microorganisms, 2022 - mdpi.com
Adaptation to the changing environmental conditions experienced within a host requires
genetic diversity within a microbial population. Genetic diversity arises from mutations which …

Morphology and its underlying genetic regulation impact the interaction between Cryptococcus neoformans and its hosts

J Lin, A Idnurm, X Lin - Medical mycology, 2015 - academic.oup.com
Cryptococcus neoformans is a fungus that causes the majority of fatal cryptococcal
meningitis cases worldwide. This pathogen is capable of assuming different morphotypes …

Immunoprotection against cryptococcosis offered by znf2 depends on capsule and the hyphal morphology

J Lin, T Pham, K Hipsher, N Glueck, Y Fan, X Lin - MBio, 2022 - Am Soc Microbiol
Systemic cryptococcosis is fatal without treatment. Globally, this disease kills 180,000 of the
225,000 infected people each year, even with the use of antifungal therapies. Currently …

One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation

S Brunke, K Seider, D Fischer, ID Jacobsen… - PLoS …, 2014 - journals.plos.org
Candida glabrata is one of the most common causes of candidemia, a life-threatening,
systemic fungal infection, and is surpassed in frequency only by Candida albicans. Major …

The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

BJ Chadwick, T Pham, X Xie, LC Ristow, DJ Krysan… - Elife, 2022 - elifesciences.org
The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO 2 concentrations has only recently been …

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

KL Ormerod, CA Morrow, EWL Chow… - G3: Genes …, 2013 - academic.oup.com
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality
among the human immunodeficiency virus/acquired immunodeficiency syndrome …