Osteoporosis is a bone disorder with remarkable changes in bone biologic material and
consequent bone structural distraction, affecting millions of people around the world from …

During the past decade preclinical studies have defined many of the mechanisms used by
tumours to hijack the skeleton and promote bone metastasis. This has led to the …

Although covalent inhibitors have been used as therapeutics for more than a century, there
has been general resistance in the pharmaceutical industry against their further …

In the beginning, that is from the 1960's, when a link between menopause and osteoporosis
was first identified; estrogen treatment was the standard for preventing bone loss, however …

Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Osteoporosis is a common disease characterised by a systemic impairment of bone mass
and microarchitecture that results in fragility fractures. With an ageing population, the …

Abstract Summary The International Osteoporosis Foundation (IOF) and the International
Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend that a marker …

Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family.
Although cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also …

It is well known that the underlying mechanisms of osteoporosis in older adults are different
than those associated with estrogen deprivation. Age-related bone loss involves a gradual …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …