Next-generation sequencing (NGS) technology has advanced our understanding of the
human microbiome by allowing for the discovery and characterization of unculturable …

SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …

Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections,
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …

Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and …

A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global
pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing …

Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Carbapenem resistance is a major and an on-going public health problem globally. It occurs
mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas …

The recent advent of DNA sequencing technologies facilitates the use of genome
sequencing data that provide means for more informative and precise classification and …