Although β-lactams have been the most effective class of antibacterial agents used in
clinical practice for the past half century, their effectiveness on Gram-negative bacteria has …

Introduction: For the past three decades, carbapenems played a central role in our antibiotic
armamentarium, trusted to effectively treat infections caused by drug-resistant bacteria. The …

Respiratory tract infections rank second as causes of adult and paediatric morbidity and
mortality worldwide. Respiratory tract infections are caused by many different bacteria …

Background Outbreaks of antibiotic-resistant bacterial infections emphasize the importance
of surveillance of potentially pathogenic bacteria. Genomic sequencing of clinical …

Large-scale bacterial genome sequencing efforts to date have provided limited information
on the most prevalent category of disease: sporadically acquired infections caused by …

Plasmids harbor genes coding for specific functions including virulence factors and antibiotic
resistance that permit bacteria to survive the hostile environment found in the host and resist …

ABSTRACT A rapid and global emergence of azole resistance has been observed in the
pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance …

Colonization of the gastrointestinal (GI) tract by Klebsiella pneumoniae is generally
considered asymptomatic. However, gut colonization allows K. pneumoniae to either …

Objective. To describe the epidemiology of carbapenem-resistant Enterobacteriaceae (CRE)
carriage and acquisition among hospitalized patients in an area of CRE endemicity. Design …

Klebsiella pneumoniae poses a major challenge to healthcare worldwide as an important
cause of multidrug-resistant infections. Nosocomial clones, including epidemic sequence …