Bacterial genome sequencing in clinical microbiology: a pathogen-oriented review

F Tagini, G Greub - European journal of clinical microbiology & infectious …, 2017 - Springer
In recent years, whole-genome sequencing (WGS) has been perceived as a technology with
the potential to revolutionise clinical microbiology. Herein, we reviewed the literature on the …

Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae

HM Zowawi, BM Forde, M Alfaresi, A Alzarouni… - Scientific reports, 2015 - nature.com
Carbapenem resistant Enterobacteriaceae (CRE) pose an urgent risk to global human
health. CRE that are non-susceptible to all commercially available antibiotics threaten to …

Infection control implications of heterogeneous resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE)

KE Goodman, PJ Simner, PD Tamma… - Expert review of anti …, 2016 - Taylor & Francis
The Centers for Disease Control and Prevention (CDC) defines carbapenem-resistant
Enterobacteriaceae (CRE) based upon a phenotypic demonstration of carbapenem …

Characterization of foodborne outbreaks of Salmonella enterica serovar Enteritidis with whole-genome sequencing single nucleotide polymorphism-based analysis …

AJ Taylor, V Lappi, WJ Wolfgang… - Journal of clinical …, 2015 - Am Soc Microbiol
Salmonella enterica serovar Enteritidis is a significant cause of gastrointestinal illness in the
United States; however, current molecular subtyping methods lack resolution for this highly …

The changing face of pathogen discovery and surveillance

WI Lipkin - Nature Reviews Microbiology, 2013 - nature.com
The pace of pathogen discovery is rapidly accelerating. This reflects not only factors that
enable the appearance and globalization of new microbial infections, but also improvements …

Next-generation sequencing and PCR technologies in monitoring the hospital microbiome and its drug resistance

C Cason, M D'Accolti, I Soffritti, S Mazzacane… - Frontiers in …, 2022 - frontiersin.org
The hospital environment significantly contributes to the onset of healthcare-associated
infections (HAIs), which represent one of the most frequent complications occurring in …

Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions

WF Fricke, DA Rasko - Nature Reviews Genetics, 2014 - nature.com
The potential of bacterial whole-genome sequencing (WGS) to complement existing
diagnostic infrastructures in clinical microbiology has been shown in proof-of-principle …

Seeking the source of Pseudomonas aeruginosa infections in a recently opened hospital: an observational study using whole-genome sequencing

J Quick, N Cumley, CM Wearn, M Niebel… - BMJ open, 2014 - bmjopen.bmj.com
Objectives Pseudomonas aeruginosa is a common nosocomial pathogen responsible for
significant morbidity and mortality internationally. Patients may become colonised or infected …

Prevention and control of multi-drug-resistant Gram-negative bacteria: recommendations from a Joint Working Party

APR Wilson, DM Livermore… - Journal of …, 2016 - journalofhospitalinfection.com
1. Executive summary Multi-drug-resistant (MDR) Gram-negative bacterial infections have
become prevalent in some European countries. Moreover, increased use of broad-spectrum …

Hospital-associated microbiota and implications for nosocomial infections

S Lax, JA Gilbert - Trends in molecular medicine, 2015 - cell.com
The rise of high-throughput sequencing technologies and culture-independent microbial
surveys has the potential to revolutionize our understanding of how microbes colonize …