Targets for combating the evolution of acquired antibiotic resistance
Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics.
Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves …
Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves …
Assuring the quality of next-generation sequencing in clinical microbiology and public health laboratories
Clinical microbiology and public health laboratories are beginning to utilize next-generation
sequencing (NGS) for a range of applications. This technology has the potential to transform …
sequencing (NGS) for a range of applications. This technology has the potential to transform …
Key parameters for genomics-based real-time detection and tracking of multidrug-resistant bacteria: a systematic analysis
Background Pairwise single nucleotide polymorphisms (SNPs) are a cornerstone of
genomic approaches to the inference of transmission of multidrug-resistant (MDR) …
genomic approaches to the inference of transmission of multidrug-resistant (MDR) …
New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis
Acinetobacter baumannii is a globally important nosocomial pathogen characterized by an
increasing incidence of multidrug resistance. Routes of dissemination and gene flow among …
increasing incidence of multidrug resistance. Routes of dissemination and gene flow among …
Within-host bacterial diversity hinders accurate reconstruction of transmission networks from genomic distance data
The prospect of using whole genome sequence data to investigate bacterial disease
outbreaks has been keenly anticipated in many quarters, and the large-scale collection and …
outbreaks has been keenly anticipated in many quarters, and the large-scale collection and …
Carbapenem-resistant Enterobacteriaceae in special populations: solid organ transplant recipients, stem cell transplant recipients, and patients with hematologic …
SM Pouch, MJ Satlin - Virulence, 2017 - Taylor & Francis
Carbapenem-resistant Enterobacteriaceae (CRE) are a major global public health concern
and pose a serious threat to immunocompromised hosts, particularly patients with …
and pose a serious threat to immunocompromised hosts, particularly patients with …
Rapid nanopore sequencing of plasmids and resistance gene detection in clinical isolates
JK Lemon, PP Khil, KM Frank… - Journal of clinical …, 2017 - Am Soc Microbiol
Recent advances in nanopore sequencing technology have led to a substantial increase in
throughput and sequence quality. Together, these improvements may permit real-time …
throughput and sequence quality. Together, these improvements may permit real-time …
New opportunities for managing acute and chronic lung infections
Lung diseases caused by microbial infections affect hundreds of millions of children and
adults throughout the world. In Western populations, the treatment of lung infections is a …
adults throughout the world. In Western populations, the treatment of lung infections is a …
Hypermucoviscosity regulator RmpD interacts with Wzc and controls capsular polysaccharide chain length
Klebsiella pneumoniae is a leading cause of nosocomial infections, including pneumonia,
bacteremia, and urinary tract infections. Treatment options are increasingly restricted by the …
bacteremia, and urinary tract infections. Treatment options are increasingly restricted by the …
Antimicrobial resistance: a One Health perspective
LH Kahn - Transactions of the Royal Society of Tropical …, 2017 - academic.oup.com
Introduction Worsening antimicrobial resistance (AMR) threatens the practice of modern
human and veterinary medicine. For decades, medicine and agriculture have blamed each …
human and veterinary medicine. For decades, medicine and agriculture have blamed each …