Pigmented ocular tissues contain melanin within the intracellular melanosomes. Drugs bind
to melanin at varying extent that ranges from no binding to extensive binding. Binding may …

Drugs across many pharmacologic classes induce corneal epithelial changes. Many of
these drugs have cationic amphiphilic structures, with a hydrophobic ring and hydrophilic …

Age-related macular degeneration is a multifactorial disease affecting the posterior segment
of the eye and is characterized by aberrant nascent blood vessels that leak blood and fluid. It …

This review assesses different clinical aspects of the various known drug-induced corneal
deposits, based on the corneal layer involved (epithelium, stroma and/or endothelium), and …

A Single Drop in the Eye – Effects on the Whole Body? - PMC Back to Top Skip to main content
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The receptor tyrosine kinase, MERTK, plays an essential role in homeostasis of the retina
via efferocytosis of shed outer nuclear segments of photoreceptors. The Royal College of …

The liver is known to be the principal site of drug metabolism. Depending on the route of
administration, especially in cases of topical and local delivery, evaluation of local drug …

P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two ATP-binding
cassette efflux transporters that are coexpressed at the human blood–brain barrier (BBB) …

Rapid developments in pharmacogenomics have been noticeable in recent years, and
much of this knowledge has improved understanding of adverse drug reactions. This …

Neovascular age-related macular degeneration (AMD) is a leading cause of vision loss
worldwide. Although intravitreal injection of anti-VEGF antibodies and VEGF Trap have …