About 8 out of 10 human embryos obtained in vitro harbour chromosomal abnormalities of
either meiotic or mitotic origin. Abnormalities of mitotic origin lead to chromosomal …

Less than half of human zygotes survive to birth, primarily due to aneuploidies of meiotic or
mitotic origin. Mitotic errors generate chromosomal mosaicism, defined by multiple cell …

Abstract Preimplantation Genetic Testing (PGT) aims to reduce the chance of an affected
pregnancy or improve success in an assisted reproduction cycle. Since the first established …

Objective To investigate a possible correlation between chromosomal aberrations and
paternal age, analyzing embryos derived from young oocyte donors, with available …

Preimplantation genetic testing for aneuploidies (PGT-A) using trophectoderm (TE) biopsy
samples is labour intensive, invasive, and subject to sampling bias. In this study, we report …

Abstract The Ion S5 (Thermo Fisher Scientific) and Miseq (Illumina) NGS systems are both
widely used in the clinical laboratories conducting PGT-A. Each system employs discrepant …

The frequent acquisition of genomic abnormalities in human preimplantation embryos is a
leading cause of pregnancy loss, but does not necessarily prohibit healthy offspring …

Miscarriage affects approximately 15% of clinically recognized pregnancies, and 1–3% of
couples experience pregnancy loss recurrently. Approximately 50–60% of miscarriages …

While chromosomal mosaicism in the embryo was observed already in the '90s using both
karyotyping and FISH technologies, the full extent of this phenomenon and the overall …

About 70% of human cleavage stage embryos show chromosomal mosaicism, falling to 20%
in blastocysts. Chromosomally mosaic human blastocysts can implant and lead to healthy …