Abstract Purpose This Position Paper aims to review and discuss the available data on
therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill …

Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

BACKGROUND: Optimal drug dosing is important to ensure adequate response to
treatment, prevent development of drug resistance and reduce drug toxicity. The aim of …

The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

Clinical breakpoints are used in clinical microbiology laboratories to categorize
microorganisms as clinically susceptible (S), intermediate (I) or resistant (R) dependent on …

Antibiotic resistance constitutes one of the most pressing public health concerns.
Antimicrobial peptides (AMPs) of multicellular organisms are considered part of a solution to …

Инфекционно-воспалительные урологические осложнения и заболевания
представляют сложную проблему, как для диагностики, так и для лечения. Частота …

The significance of plasma protein binding on drug efficacy and, subsequently, the clinical
relevance of changes in protein binding has been controversially discussed for decades …

Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …