Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

This chapter presents an introduction to the kinetic analysis of SPR biosensor data for the
determination of affinity and kinetic rate constants of biomolecular interactions between an …

Surface plasmon resonance (SPR) is a phenomenon occuring at metal surfaces (typically
gold and silver) when an incident light beam strikes the surface at a particular angle …

Surface-based binding assays are often influenced by the transport of analyte to the sensor
surface. Using simulated data sets, we test a simple two-compartment model to see if its …

We provide analysis of different regimes of diffusion and laminar flow convection combined
with bimolecular surface reactions relevant to biochemical assays performed in microfluidic …

This review article presents an overview of some of the tools, techniques and applications of
numerical simulation for integrated microfluidic devices. Provided is a broad overview of the …

The theory of a method for determining active concentration of nonpurified protein samples
using the BIAcore biosensor technology has been developed. The method relies on change …

Progress has been made in the identification of experimental and analytical procedures that
allow for a more reliable determination of equilibrium and kinetic constants. Possible origins …

The marriage of microfluidics with detection technologies that rely on highly selective nucleic
acid hybridization will provide improvements in bioanalytical methods for purposes such as …

The cap structure and the poly (A) tail of eukaryotic mRNAs act synergistically to enhance
translation. This effect is mediated by a direct interaction of eukaryotic initiation factor 4G and …