Synopsis Combining tazobactam, a β-lactamase inhibitor, with the ureidopenicillin,
piperacillin, successfully restores the activity of piperacillin against β-lactamase-producing …

Piperacillin/tazobactam is a new combination of a broad-spectrum penicillin and a beta-
lactamase inhibitor. In studies in healthy volunteers, the pharmacokinetics of piperacillin …

Despite β-lactamase inhibitors being available for clinical use for nearly 30 years, a paucity
of data exists describing the pharmacokinetic-pharmacodynamic (PK-PD) determinants of …

We recently investigated the pharmacokinetics-pharmacodynamics (PK-PD) of tazobactam
in combination with ceftolozane against an isogenic CTX-M-15-producing Escherichia coli …

The aim of the present study was to evaluate the benefit of monitoring serum piperacillin
concentrations in critically ill patients. This was an 11-month, prospective, observational …

Piperacillin/tazobactam is the most recently approved combination of a β-lactam agent with
an inhibitor of bacterial β-lactamases. It has a broader spectrum than do preceding inhibitor …

We previously demonstrated that for tazobactam administered in combination with
ceftolozane, the pharmacokinetic-pharmacodynamic (PK-PD) index that best described …

Piperacillin/tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity against most Gram-positive and Gram-negative aerobic …

With the introduction of piperacillin/tazobactam to the North American market, hospitals have
been faced with the task of making a decision regarding its formulary role. In view of its …

Piperacillin extends the spectrum of activity of ampicillin to include most strains of
Pseudomonas aeruginosa, Enterobacteriaceae (non-β-lactamase-producing), many …