The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Improvements in early interventions after acute myocardial infarction (AMI), notably, the
increased use of timely reperfusion therapy, have increased survival dramatically in recent …

Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

Fibrosis is a pivotal player in heart failure development and progression. Measurements of
(markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with …

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Rationale: An exaggerated or persistent inflammatory activation after myocardial infarction
(MI) leads to maladaptive healing and subsequent remodeling of the left ventricle. Foxp3+ …

In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …