[PDF][PDF] Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity

Y Cao - Cell metabolism, 2013 - cell.com
White and brown adipose tissues are hypervascularized and the adipose vasculature
displays phenotypic and functional plasticity to coordinate with metabolic demands of …

The role of the islet niche on beta cell structure and function

E Lammert, P Thorn - Journal of molecular biology, 2020 - Elsevier
The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

[PDF][PDF] Endogenous reprogramming of alpha cells into beta cells, induced by viral gene therapy, reverses autoimmune diabetes

X Xiao, P Guo, C Shiota, T Zhang, GM Coudriet… - Cell stem cell, 2018 - cell.com
Successful strategies for treating type 1 diabetes need to restore the function of pancreatic
beta cells that are destroyed by the immune system and overcome further destruction of …

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

X Xiao, I Gaffar, P Guo, J Wiersch… - Proceedings of the …, 2014 - National Acad Sciences
Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell
therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic …

[HTML][HTML] No evidence for β cell neogenesis in murine adult pancreas

X Xiao, Z Chen, C Shiota, K Prasadan… - The Journal of …, 2013 - Am Soc Clin Investig
Whether facultative β cell progenitors exist in the adult pancreas is a major unsolved
question. To date, lineage-tracing studies have provided conflicting results. To track β cell …

The β-cell/EC axis: how do islet cells talk to each other?

H Peiris, CS Bonder, PTH Coates, DJ Keating… - Diabetes, 2014 - Am Diabetes Assoc
Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …

[HTML][HTML] Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation

S Narayanan, G Loganathan… - World journal of …, 2017 - ncbi.nlm.nih.gov
The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

[HTML][HTML] Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7

N Song, H Liu, X Ma, S Zhang - Cellular Physiology and Biochemistry, 2015 - karger.com
Background/Aims: Elucidation of the molecular mechanisms underlying ovarian cancer (OC)
cell invasion and migration may provide important evidence for developing efficient therapy …

[HTML][HTML] Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p

L Zhu, Q Zhong, T Yang, X Xiao - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent
metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) …

Pancreatic duct cells as a source of VEGF in mice

X Xiao, K Prasadan, P Guo, Y El-Gohary, S Fischbach… - Diabetologia, 2014 - Springer
Aims/hypothesis Vascular endothelial growth factor (VEGF) is essential for proper pancreatic
development, islet vascularisation and insulin secretion. In the adult pancreas, VEGF is …