Background/Aims: The current treatments fail to provide satisfactory cure for aggressive
prostate cancers (PCs). Hence, further comprehension of PC metastasis is highly …

Although antivascular endothelial growth factor a (VEGFa) treatment has been well applied
in cervical cancer therapy, the underlying molecular basis has not been precisely identified …

The malignancy of non-small cell lung cancer (NSCLC) is largely due to its invasion. Hence,
prevention of the cancer cell invasion, which is essentially regulated by vascular endothelial …

Background/Aims: Age-related macular degeneration (AMD) appears to be a disease with
increasing incidence in Western countries and may develop into acquired blindness …

Many patients with chronic pancreatitis develop diabetes (chronic pancreatitis–related
diabetes [CPRD]) through an undetermined mechanism. Here we used long-term partial …

Background/Aims: Neovascularization and invasion coordinate cancer metastases in non-
small cell lung cancer (NSCLC). However, the underlying molecular mechanisms are poorly …

A thorough understanding of the signaling pathways involved in the regulation of β cell
proliferation is an important initial step in restoring β cell mass in the diabetic patient. Here …

Background Recovery from a foot ulcer is compromised in a diabetic status, due to the
impaired tissue microenvironment that consists of altered inflammation, angiogenesis and …

Cancer stem cells (CSCs) are a distinct population in tumors and cause cancer relapse and
metastasis. Thus, treating CSCs are believed to be potential to cure rapidly growing and …

It remains controversial whether adult pancreatic ducts harbor facultative beta cell
progenitors. Because neurogenin3 (Ngn3) is a key determinant of pancreatic endocrine cell …