Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene
expression. The different RNA species that are produced in the nucleus are exported …

Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation
machinery to a highly localized domain at the 5′ portion of active mRNA coding regions …

The essential yeast proteins Yra1 and Sub2 are messenger RNA export factors that have
conserved counterparts in metazoans, designated Aly and UAP56, respectively,,,,,,. These …

Gene expression in eukaryotes requires several multi-component cellular machines. Each
machine carries out a separate step in the gene expression pathway, which includes …

Genome-wide location analysis, also known as ChIP-Chip, combines chromatin
immunoprecipitation and DNA microarray analysis to identify protein-DNA interactions that …

In yeast, the TREX complex contains the THO transcription elongation complex, which
functions in direct cotranscriptional recruitment of the mRNA export proteins Sub2 and Yra1 …

Messenger RNAs (mRNAs) are at the center of the central dogma of molecular biology. In
eukaryotic cells, these long ribonucleic acid polymers do not exist as naked transcripts; …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …

Much of the complex process of RNP biogenesis takes place at the gene cotranscriptionally.
The target for RNA binding and processing factors is, therefore, not a solitary RNA molecule …