Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control
Synaptogenesis is essential for circuit development; however, it is unknown whether it is
critical for the establishment and performance of goal-directed voluntary behaviors. Here, we …
critical for the establishment and performance of goal-directed voluntary behaviors. Here, we …
Social experience in adolescence shapes prefrontal cortex structure and function in adulthood
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC
development is profoundly influenced by the social environment, disruptions to which may …
development is profoundly influenced by the social environment, disruptions to which may …
Medial orbitofrontal neurotrophin systems integrate hippocampal input into outcome-specific value representations
EP Woon, LM Butkovich, AA Peluso, A Elbasheir… - Cell reports, 2022 - cell.com
In everyday life, we mentally represent possible consequences of our behaviors and
integrate specific outcome values into existing knowledge to inform decisions. The medial …
integrate specific outcome values into existing knowledge to inform decisions. The medial …
Neuronal ensembles in the amygdala allow social information to motivate later decisions
HW Kietzman, G Trinoskey-Rice, EH Seo… - Journal of …, 2024 - Soc Neuroscience
Social experiences carry tremendous weight in our decision-making, even when social
partners are not present. To determine mechanisms, we trained female mice to respond for …
partners are not present. To determine mechanisms, we trained female mice to respond for …
Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala
The dorsomedial striatum (DMS) is associated with flexible goal seeking, as opposed to
routinized habits. Whether local mechanisms brake this function, for instance when habits …
routinized habits. Whether local mechanisms brake this function, for instance when habits …
A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit
ST Yount, S Wang, AT Allen, LP Shapiro… - Progress in …, 2024 - Elsevier
Habits are familiar behaviors triggered by cues, not outcome predictability, and are
insensitive to changes in the environment. They are adaptive under many circumstances but …
insensitive to changes in the environment. They are adaptive under many circumstances but …
How Celebrity Endorsement Affects Travel Intention: Evidence From Tourism Live Streaming
L Zhang, D Shi, Z Huang, A Zhang… - Journal of Hospitality & …, 2024 - journals.sagepub.com
Celebrity endorsements via live streaming continue to draw attention in the tourism industry.
This research examines the effects of such endorsements on tourism live streaming. We …
This research examines the effects of such endorsements on tourism live streaming. We …
Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making
L Qiu, Y Qiu, J Liao, J Li, X Zhang, K Chen, Q Huang… - Iscience, 2024 - cell.com
Inferring prospective outcomes and updating behavior are prerequisites for making flexible
decisions in the changing world. These abilities are highly associated with the functions of …
decisions in the changing world. These abilities are highly associated with the functions of …
Identification of patients with internet gaming disorder via a radiomics-based machine learning model of subcortical structures in high-resolution T1-weighted MRI
L Wang, L Zhou, S Liu, Y Zheng, Q Liu, M Yu… - Progress in Neuro …, 2024 - Elsevier
It is of vital importance to establish an objective and reliable model to facilitate the early
diagnosis and intervention of internet gaming disorder (IGD). A total of 133 patients with IGD …
diagnosis and intervention of internet gaming disorder (IGD). A total of 133 patients with IGD …
GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae
DC Li, EG Pitts, NM Dighe, SL Gourley - Neuropsychopharmacology, 2023 - nature.com
Cocaine self-administration can disrupt the capacity of humans and rodents to flexibly
modify familiar behavioral routines, even when they become maladaptive or unbeneficial …
modify familiar behavioral routines, even when they become maladaptive or unbeneficial …