Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control

FP Ulloa Severino, OO Lawal, K Sakers… - Nature …, 2023 - nature.com
Synaptogenesis is essential for circuit development; however, it is unknown whether it is
critical for the establishment and performance of goal-directed voluntary behaviors. Here, we …

Social experience in adolescence shapes prefrontal cortex structure and function in adulthood

DC Li, EA Hinton, J Guo, KA Knight, MK Sequeira… - Molecular …, 2024 - nature.com
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC
development is profoundly influenced by the social environment, disruptions to which may …

Medial orbitofrontal neurotrophin systems integrate hippocampal input into outcome-specific value representations

EP Woon, LM Butkovich, AA Peluso, A Elbasheir… - Cell reports, 2022 - cell.com
In everyday life, we mentally represent possible consequences of our behaviors and
integrate specific outcome values into existing knowledge to inform decisions. The medial …

Neuronal ensembles in the amygdala allow social information to motivate later decisions

HW Kietzman, G Trinoskey-Rice, EH Seo… - Journal of …, 2024 - Soc Neuroscience
Social experiences carry tremendous weight in our decision-making, even when social
partners are not present. To determine mechanisms, we trained female mice to respond for …

Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala

EC Heaton, EH Seo, LM Butkovich, ST Yount… - Progress in …, 2024 - Elsevier
The dorsomedial striatum (DMS) is associated with flexible goal seeking, as opposed to
routinized habits. Whether local mechanisms brake this function, for instance when habits …

A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit

ST Yount, S Wang, AT Allen, LP Shapiro… - Progress in …, 2024 - Elsevier
Habits are familiar behaviors triggered by cues, not outcome predictability, and are
insensitive to changes in the environment. They are adaptive under many circumstances but …

How Celebrity Endorsement Affects Travel Intention: Evidence From Tourism Live Streaming

L Zhang, D Shi, Z Huang, A Zhang… - Journal of Hospitality & …, 2024 - journals.sagepub.com
Celebrity endorsements via live streaming continue to draw attention in the tourism industry.
This research examines the effects of such endorsements on tourism live streaming. We …

Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making

L Qiu, Y Qiu, J Liao, J Li, X Zhang, K Chen, Q Huang… - Iscience, 2024 - cell.com
Inferring prospective outcomes and updating behavior are prerequisites for making flexible
decisions in the changing world. These abilities are highly associated with the functions of …

Identification of patients with internet gaming disorder via a radiomics-based machine learning model of subcortical structures in high-resolution T1-weighted MRI

L Wang, L Zhou, S Liu, Y Zheng, Q Liu, M Yu… - Progress in Neuro …, 2024 - Elsevier
It is of vital importance to establish an objective and reliable model to facilitate the early
diagnosis and intervention of internet gaming disorder (IGD). A total of 133 patients with IGD …

GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae

DC Li, EG Pitts, NM Dighe, SL Gourley - Neuropsychopharmacology, 2023 - nature.com
Cocaine self-administration can disrupt the capacity of humans and rodents to flexibly
modify familiar behavioral routines, even when they become maladaptive or unbeneficial …