Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Leptin in Leanness and Obesity: JACC State-of-the-Art Review

N Perakakis, OM Farr, CS Mantzoros - Journal of the American College of …, 2021 - jacc.org
Leptin has emerged over the past 2 decades as a key hormone secreted by adipose tissue
that conveys information on energy stores. Leptin is considered an important regulator of …

From non-alcoholic fatty liver disease (NAFLD) to steatotic liver disease (SLD): an ongoing journey towards refining the terminology for this prevalent metabolic …

M Kokkorakis, C Boutari, N Katsiki… - Metabolism-Clinical …, 2023 - metabolismjournal.com
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic condition closely
associated with genetic predisposition and/or obesity, lipodystrophy, and insulin resistance …

Liver biopsy-based validation, confirmation and comparison of the diagnostic performance of established and novel non-invasive steatotic liver disease indexes …

M Kouvari, L Valenzuela-Vallejo, V Guatibonza-Garcia… - Metabolism, 2023 - Elsevier
Background Non-invasive tools (NIT) for metabolic-dysfunction associated liver disease
(MASLD) screening or diagnosis need to be thoroughly validated using liver biopsies …

[HTML][HTML] Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP)

M Rizzo, A Colletti, PE Penson, N Katsiki… - Pharmacological …, 2023 - Elsevier
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition affecting around
10–25% of the general adult population, 15% of children, and even> 50% of individuals who …

Diagnostic modalities of non-alcoholic fatty liver disease: from biochemical biomarkers to multi-omics non-invasive approaches

E Martinou, M Pericleous, I Stefanova, V Kaur… - Diagnostics, 2022 - mdpi.com
Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common cause of chronic
liver disease worldwide, and its prevalence is increasing globally. NAFLD is a multifaceted …

Perspectives on precision medicine approaches to NAFLD diagnosis and management

A Lonardo, JP Arab, M Arrese - Advances in Therapy, 2021 - Springer
Precision medicine defines the attempt to identify the most effective approaches for specific
subsets of patients based on their genetic background, clinical features, and environmental …

Time to transition from a negative nomenclature describing what NAFLD is not, to a novel, pathophysiology-based, umbrella classification of fatty liver disease (FLD)

L Valenzuela-Vallejo, CS Mantzoros - Metabolism, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a definition of a prevalent condition that has
been given a name describing what the disease is not, mainly due to gaps in the …

Precision medicine in fatty liver disease/non-alcoholic fatty liver disease

L Valenzuela-Vallejo, D Sanoudou… - Journal of Personalized …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, and is
related to fatal and non-fatal liver, metabolic, and cardiovascular complications. Its non …

Liver fat as risk factor of hepatic and cardiometabolic diseases

M Demir, SR Bornstein, CS Mantzoros… - Obesity …, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive
accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic …