HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

BACKGROUND Recurrent miscarriage and pre-eclampsia are common reproductive
disorders, but their causes are often unknown. Recent evidence has provided new insight …

Cells isolated from Wharton's jelly, referred to as umbilical cord matrix stromal (UCMS) cells,
adhere to a tissue-culture plastic substrate, express mesenchymal stromal cell (MSC) …

The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …

Preeclampsia is a pregnancy-associated disorder characterized by hypertension, and could
lead to maternal and fetal morbidity and mortality; however, the pathophysiological …

Antigen‐presenting molecules vary between individuals of the same species, making it more
difficult for pathogens to evade immune recognition and spread through the whole …

The relevance of the nonclassical human leukocyte antigen (HLA) class I molecule HLA-G in
human physiological and pathological contexts has been the center of intense investigation …

BACKGROUND Pre-eclampsia is a syndrome of heterogeneous origin characterized by
deficient placentation due to the inability of the cytotrophoblast to acquire an invasive …

Regulatory T cells, a subpopulation of suppressive T cells, are potent mediators of self-
tolerance and essential for the suppression of triggered immune responses. The immune …

Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex
(MHC) class I molecule that functions as an immunomodulatory molecule capable of …