The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

Body weight is regulated by interoceptive neural circuits that track energy need, but how the
activity of these circuits is altered in obesity remains poorly understood. Here we describe …

The aim of this review is to explore how metabolic changes induced by diets high in
saturated fat (HFD) affect nucleus accumbens (NAc) dopamine neurotransmission and food …

Psilocybin and other serotonergic psychedelics have re-emerged as therapeutics for
neuropsychiatric disorders, including addiction. Psilocybin induces long-lasting effects on …

The role of stress, trauma, and adversity particularly early in life has been identified as a
contributing factor in both drug and food addictions. While links between traumatic stress …

Dementia comprises a wide range of progressive and acquired neurocognitive disorders.
Obesity, defined as excessive body fat tissue, is a common health issue world-wide and a …

Dopamine is a neurotransmitter that plays a crucial role in adaptive behavior. A wealth of
studies suggests obesity-related alterations in the central dopamine system. The most direct …

Precise neural regulation is required for maintenance of energy homeostasis. Essential to
this are the hypothalamic and brainstem nuclei which are located adjacent and supra …

The experimental study of learning and plasticity has always been driven by an implicit
question: how can physiological changes be adaptive and improve performance? For …