The past, present and future of anti-malarial medicines

EG Tse, M Korsik, MH Todd - Malaria journal, 2019 - Springer
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Recent progress in the development of new antimalarial drugs with novel targets

TM Belete - Drug design, development and therapy, 2020 - Taylor & Francis
Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

A Amambua-Ngwa, KA Button-Simons, X Li… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

Triple artemisinin-based combination therapies for malaria–a new paradigm?

RW van der Pluijm, C Amaratunga, M Dhorda… - Trends in …, 2021 - cell.com
Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …

[HTML][HTML] Artemisinin and multidrug-resistant Plasmodium falciparum–a threat for malaria control and elimination

M Dhorda, C Amaratunga… - Current opinion in …, 2021 - journals.lww.com
Enhancing the geographic coverage of surveillance for resistance will be key to ensure
prompt detection of emerging resistance in order to implement effective countermeasures …

The fight against malaria: diminishing gains and growing challenges

JM Cohen, F Okumu, B Moonen - Science Translational Medicine, 2022 - science.org
Since the year 2000, historic reductions in malaria incidence and mortality have been driven
by the widespread distribution of bed nets, drugs, and insecticides for the prevention and …

Resistance to artemisinin combination therapies (ACTs): do not forget the partner drug!

C Nsanzabana - Tropical medicine and infectious disease, 2019 - mdpi.com
Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …

[HTML][HTML] Drug discovery for chagas disease: A viewpoint

JM Kratz - Acta tropica, 2019 - Elsevier
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …

Combination therapy strategies for the treatment of malaria

S Alven, B Aderibigbe - Molecules, 2019 - mdpi.com
Malaria is a vector-and blood-borne infection that is responsible for a large number of
deaths around the world. Most of the currently used antimalarial therapeutics suffer from …

Potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle: structures, mechanisms, and clinical trials

RA Al-Horani, S Kar, KF Aliter - International Journal of Molecular …, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present …