The past, present and future of anti-malarial medicines
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
Recent progress in the development of new antimalarial drugs with novel targets
TM Belete - Drug design, development and therapy, 2020 - Taylor & Francis
Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …
annually. The therapeutic options are scarce and massively challenged by the emergence of …
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
A Amambua-Ngwa, KA Button-Simons, X Li… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …
Triple artemisinin-based combination therapies for malaria–a new paradigm?
RW van der Pluijm, C Amaratunga, M Dhorda… - Trends in …, 2021 - cell.com
Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …
[HTML][HTML] Artemisinin and multidrug-resistant Plasmodium falciparum–a threat for malaria control and elimination
M Dhorda, C Amaratunga… - Current opinion in …, 2021 - journals.lww.com
Enhancing the geographic coverage of surveillance for resistance will be key to ensure
prompt detection of emerging resistance in order to implement effective countermeasures …
prompt detection of emerging resistance in order to implement effective countermeasures …
The fight against malaria: diminishing gains and growing challenges
Since the year 2000, historic reductions in malaria incidence and mortality have been driven
by the widespread distribution of bed nets, drugs, and insecticides for the prevention and …
by the widespread distribution of bed nets, drugs, and insecticides for the prevention and …
Resistance to artemisinin combination therapies (ACTs): do not forget the partner drug!
C Nsanzabana - Tropical medicine and infectious disease, 2019 - mdpi.com
Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …
[HTML][HTML] Drug discovery for chagas disease: A viewpoint
JM Kratz - Acta tropica, 2019 - Elsevier
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
Combination therapy strategies for the treatment of malaria
S Alven, B Aderibigbe - Molecules, 2019 - mdpi.com
Malaria is a vector-and blood-borne infection that is responsible for a large number of
deaths around the world. Most of the currently used antimalarial therapeutics suffer from …
deaths around the world. Most of the currently used antimalarial therapeutics suffer from …
Potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle: structures, mechanisms, and clinical trials
RA Al-Horani, S Kar, KF Aliter - International Journal of Molecular …, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present …
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present …