Tablets are the most widely utilized solid oral dosage forms because of the advantages of
self-administration, stability, ease of handling, transportation, and good patient compliance …

Paroxetine (PX) is the most potent serotonin reuptake inhibitor utilized in depression and
anxiety treatment. It has drawbacks, such as having a very bitter taste, low water solubility …

Context Diacerein (DCN) has low aqueous solubility (3.197 mg/L) and, consequently, low
oral bioavailability (35%–56%). To increase both the solubility and dissolution rate of DCN …

This research aimed at developing ODFs containing an antipsychotic drug–aripiprazole
(ARP). ARP, as a BCS II class molecule, requires enhancing its water solubility prior to …

Felodipine (FDP), a dihydropyridine calcium-channel antagonist is used for the treatment of
hypertension and angina pectoris. FDP is poorly soluble drug and upon oral administration …

Carvedilol (CAR) is a potent antihypertensive drug but has poor oral bioavailability (24%). A
nanosuspension suitable for pulmonary delivery to enhance bioavailability and bypass first …

Olmesartan medoxomil (OM) is an antihypertensive drug with poor water solubility and low
oral bioavailability (28.6%). Accordingly, this study aimed to formulate and evaluate OM …

Central nervous system (CNS) disorders have been incorporated into our daily lifestyle now
and in general, are faced by people of all age-groups and affect both men and women …

The blood-brain barrier (BBB) prevents the passage of many drugs that target the central
nervous system (CNS). The BBB represents a structure with a complex cellular organization …

The aim of this study was to design a novel carrier for enhancing the bioavailability of the
poorly water-soluble drug, aripiprazole (ARP). Silicosan, the applied carrier, was obtained …