Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

Cancers have dysfunctional redox regulation resulting in reactive oxygen species
production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized …

Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …

Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event
is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in …

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …

The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured
signaling pathways that recognize and repair DNA damage, and the immune response to …

Reactive oxygen and nitrogen species (eg H 2 O 2, nitric oxide) confer redox regulation of
essential cellular signaling pathways such as cell differentiation, proliferation, migration and …

Historically, cancers have been treated with chemotherapeutics aimed to have profound
effects on tumor cells with only limited effects on normal tissue. This approach was followed …

Reactive oxygen and nitrogen species damage cellular macromolecules including DNA.
Cells have a robust base excision repair pathway to deal with this damage in both nuclear …