Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy

M Rudraraju, SP Narayanan, PR Somanath - Pharmacological research, 2020 - Elsevier
Loss of the blood-retinal barrier (BRB) integrity and subsequent damage to the
neurovascular unit in the retina are the underlying reasons for diabetic retinopathy (DR) …

Cell-cell junctions: structure and regulation in physiology and pathology

MS Adil, SP Narayanan, PR Somanath - Tissue Barriers, 2021 - Taylor & Francis
Epithelial and endothelial cell-cell contacts are established and maintained by several
intercellular junctional complexes. These structurally and biochemically differentiated …

Network pharmacology-based prediction and verification of the active ingredients and potential targets of zuojinwan for treating colorectal cancer

S Huang, Z Zhang, W Li, F Kong, P Yi… - Drug Design …, 2020 - Taylor & Francis
Background Zuojinwan (ZJW), a famous Chinese medicine formula, has been widely used
to treat colorectal cancer (CRC). However, its bioactive compounds, potential targets, and …

[HTML][HTML] Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review

E Verma, A Kumar, UD Daimary, D Parama… - Journal of Functional …, 2021 - Elsevier
Cancer is one of the deadliest diseases worldwide which kills approximately 10 million
people annually. Although, substantial improvements have been made in the treatment …

Targeting Akt-associated microRNAs for cancer therapeutics

MS Adil, D Khulood, PR Somanath - Biochemical pharmacology, 2021 - Elsevier
The uncontrolled growth and spread of abnormal cells because of activating
protooncogenes and/or inactivating tumor suppressor genes are the hallmarks of cancer …

[HTML][HTML] Integrating network pharmacology and experimental validation to investigate the mechanisms of Huazhuojiedu decoction to treat chronic atrophic gastritis

X Hao, Y Liu, P Zhou, Q Jiang, Z Yang, M Xu… - Evidence-based …, 2020 - hindawi.com
Background. Chronic atrophic gastritis (CAG) is an important stage in the normal gastric
mucosa's transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese …

Endothelial permeability assays in vitro

MS Adil, PR Somanath - Permeability Barrier: Methods and Protocols, 2021 - Springer
The endothelium is a thin layer of squamous cells that acts as a semipermeable barrier
regulating vascular permeability to let molecules pass through it thereby maintaining tissue …

[HTML][HTML] Network pharmacology and transcriptomic sequencing analyses reveal the molecular mechanism of Sanguisorba officinalis against colorectal cancer

W Zhang, S Sang, C Peng, GQ Li, L Ou, Z Feng… - Frontiers in …, 2022 - frontiersin.org
Background: Colorectal cancer (CRC) is the most common malignant cancer worldwide.
Sanguisorba officinalis has been shown to have anti-inflammatory, anti-bacterial, antioxidant …

[HTML][HTML] Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease

W Xu, B Ren, Z Zhang, C Chen, T Xu, S Liu… - Frontiers in …, 2022 - frontiersin.org
There is yet no effective drug for Alzheimer's disease (AD) which is one of the world's most
common neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) is derived …

Current situation, trend, and prospects of research on functional components from by-products of baijiu production: A Review

Y Jiang, J Sun, J Chandrapala, M Majzoobi… - Food Research …, 2024 - Elsevier
In the present scenario marked by energy source shortages and escalating concerns
regarding carbon dioxide emissions, there is a growing emphasis on the optimal utilization …