Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …

Chronic airway diseases are characterized by airway inflammation, obstruction, and
remodeling and show high prevalence, especially in developing countries. Among them …

Allergic asthma is defined as asthma associated with sensitization to aeroallergens, which
leads to asthma symptoms and airway inflammation. Allergic asthma is the most common …

Asthma is a common complex disease of the airways. Genome-wide association studies
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …

Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an
important factor in separating the phenotypes. Genetic factors, atopy, and early respiratory …

Severe asthma (SA) afflicts a heterogeneous group of asthma patients who exhibit poor
responses to traditional asthma medications. SA patients likely represent 5–10% of all …

Abstract The Global Initiative for Asthma (GINA) is a network of individuals, organizations,
and public health officials that was established to disseminate information about the care of …

Transportation noise leads to sleep disturbance and to psychological and physiological
sustained stress reactions, which could impact respiratory health. However, epidemiologic …

Background Epidemiologic evidence indicates common risk factors, including air pollution
exposure, for respiratory and cardiovascular diseases, suggesting the involvement of …

A paradigm shift brought by the recognition that childhood asthma is an aggregated
diagnosis that comprises several different endotypes underpinned by different …