Over time, there has been a shift in the paradigm of asthma, from a single-disease concept
toward a greater recognition of asthma as a complex, chronic disease with marked clinical …

Identifying preventable exposures that lead to asthma and associated allergies has proved
challenging, partly because of the difficulty in differentiating phenotypes that define …

Asthma is a complex chronic inflammatory disease of the airways caused by the interaction
of genetic susceptibility with environmental influences. Genome-wide association studies …

Background: Many genes associated with asthma explain only a fraction of its heritability.
Most genome-wide association studies (GWASs) used a broad definition of 'doctor …

Acute kidney injury (AKI) is a frequently encountered syndrome especially among the
critically ill. Current diagnosis of AKI is based on acute deterioration of kidney function …

Background We previously identified two acute kidney injury (AKI) sub-phenotypes (AKI-SP1
and AKI-SP2) with different risk of poor clinical outcomes and response to vasopressor …

Background Animal data have suggested that the transient receptor potential ankyrin‐1
(TRPA 1) ion channel plays a key role in promoting airway inflammation in asthma and may …

Exposure to different organisms (bacteria, mold, virus, protozoan, helminths, among others)
can induce epigenetic changes affecting the modulation of immune responses and …

Background The extent of differences between genetic risks associated with various asthma
subtypes is still unknown. To better understand the heterogeneity of asthma, we employed …

The astounding number of genetic variants revealed in the 15 years of genome-wide
association studies of asthma has not kept pace with the goals of translational genomics …