Malaria: an overview

M Fikadu, E Ashenafi - Infection and Drug Resistance, 2023 - Taylor & Francis
Malaria is a global public health burden with an estimated 229 million cases reported
worldwide in 2019. About 94% of the reported cases were recorded in the African region …

Human cytochrome P450 1, 2, 3 families as pharmacogenes with emphases on their antimalarial and antituberculosis drugs and prevalent African alleles

CR Chamboko, W Veldman, RB Tata… - International Journal of …, 2023 - mdpi.com
Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Where have all the diagnostic morphological parasitologists gone?

RS Bradbury, SGH Sapp, I Potters… - Journal of clinical …, 2022 - Am Soc Microbiol
Advances in laboratory techniques have revolutionized parasitology diagnostics over the
past several decades. Widespread implementation of rapid antigen detection tests has …

Prevalence of asymptomatic malaria and associated factors among pregnant women in Ethiopia: systematic review and meta-analysis

T Duguma, E Tekalign, SS Kebede… - Frontiers in Reproductive …, 2023 - frontiersin.org
The proactive identification of asymptomatic patients and the mitigation of associated
problems are essential to the elimination of malaria. For asymptomatic malaria and related …

Updates on traditional methods for combating malaria and emerging Wolbachia-based interventions

I Mushtaq, MS Sarwar, A Chaudhry… - Frontiers in Cellular …, 2024 - frontiersin.org
The escalating challenge of malaria control necessitates innovative approaches that extend
beyond traditional control strategies. This review explores the incorporation of traditional …

[HTML][HTML] Mass testing and treatment to accelerate malaria elimination: A systematic review and meta-analysis

B Bhamani, EM Coma-Cros, M Tusell… - The American Journal …, 2024 - ncbi.nlm.nih.gov
In regions where malaria transmission persists, the implementation of approaches aimed at
eliminating parasites from the population can effectively decrease both burden of disease …

Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa

LC Okell, TK Kwambai, A Dhabangi… - Nature …, 2023 - nature.com
Children recovering from severe malarial anaemia (SMA) remain at high risk of readmission
and death after discharge from hospital. However, a recent trial found that post-discharge …

Economic evaluation of postdischarge malaria chemoprevention in preschool children treated for severe anaemia in Malawi, Kenya, and Uganda: A cost-effectiveness …

MJ Kühl, T Gondwe, A Dhabangi, TK Kwambai… - …, 2022 - thelancet.com
Background Children hospitalised with severe anaemia in malaria-endemic areas are at a
high risk of dying or being readmitted within six months of discharge. A trial in Kenya and …

Case Series of Primaquine-Induced Haemolytic Events in Controlled Trials with G6PD Screening

A Kosasih, R James, NH Chau, MM Karman… - Pathogens, 2023 - mdpi.com
Primaquine for radical cure of Plasmodium vivax malaria poses a potentially life-threatening
risk of haemolysis in G6PD-deficient patients. Herein, we review five events of acute …

Ex vivo transdermal delivery of 3 H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted …

S Morris, M Long, A Savage, A Owen, S Rannard… - Nanoscale …, 2023 - pubs.rsc.org
Inherent barrier properties of the skin impose significant challenges to the transdermal
delivery of drugs to systemic circulation. Here, the ex vivo transdermal permeation and …