Premature Ovarian Failure and Ovarian Autoimmunity* | Endocrine Reviews | Oxford
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A large body of information about antigen receptors on the surface of T lymphocytes has
been gathered in the last five years (1, 2). T cell receptors use a variable region gene pool …

To develop a therapy for drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we
transduced T lymphocytes with anti-CD19 chimeric receptors, consisting of an anti-CD19 …

The T-cell repertoire is elaborated by a still poorly understood process during which
precursor cells arising in the bone marrow seed the thymus to provide a starting point for …

Recent studies on the structure of the B cell antigen receptor demonstrate that the
membrane-bound and antigen-binding immunoglobulin molecules are noncovalently …

The mechanism by which cell surface molecules regulate T cell production of lymphokines is
poorly understood. Production of interleukin-2 (IL-2) can be regulated by signal transduction …

The ability to discriminate between self and nonself antigens is vital to the functioning of the
immune system as a specific defense against invading microorganisms. Failure of the …

T cells bearing yi3 antigen receptors constitute minor populations in most peripheral
lymphoid tissues but represent the major populations of T cells in certain epithelia, including …

Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice,
but the mechanisms of the tumor-induced immune defects remain poorly understood. In an …

The central nervous system has long been considered an immunologically privileged site.
Nevertheless, cells derived from the bone marrow can and do enter the CNS in a number of …