Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Simple Summary Alzheimer's disease (AD) is the most common neurodegenerative disease,
intensifying impairments in cognition, behavior, and memory. Histopathological AD …

Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

Abstract Alzheimer's disease (AD), as a progressive and irreversible brain disorder, remains
the most universal neurodegenerative disease. No effective therapeutic methods are …

Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …

Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Alzheimer's disease (AD), the most common form of dementia, is a progressive and
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …

Alzheimer's Disease (AD) remains one of the most challenging health-related issues for our
society. It is becoming increasingly prevalent, especially in developed countries, due to the …