Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions

C Savoia, EL Schiffrin - Clinical science, 2007 - portlandpress.com
More than 80% of patients with type 2 diabetes mellitus develop hypertension, and approx.
20% of patients with hypertension develop diabetes. This combination of cardiovascular risk …

Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation

D Fliser, K Buchholz, H Haller - Circulation, 2004 - Am Heart Assoc
Background—Experimental studies revealed proinflammatory properties of angiotensin II.
We evaluated antiinflammatory effects of the angiotensin II subtype 1 receptor antagonist …

Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells

X Pang, J Liu, J Zhao, J Mao, X Zhang, L Feng, C Han… - Atherosclerosis, 2014 - Elsevier
Abstract Objective Homocysteine (Hcy) is known as an independent risk factor for
atherosclerosis. C-reactive protein (CRP) directly participates in initiation and progression of …

The relationship between inflammation and venous thrombosis

EA Fox, SR Kahn - Thrombosis and haemostasis, 2005 - thieme-connect.com
During the past decade, the role of inflammation in the pathophysiology of arterial
thrombosis has been elucidated. However, comparatively little is known about the …

C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E–deficient mice

A Paul, KWS Ko, L Li, V Yechoor, MA McCrory… - Circulation, 2004 - Am Heart Assoc
Background—Plasma C-reactive protein (CRP) concentration is a strong predictor of
atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic …

C-reactive protein and cardiovascular disease: new insights from an old molecule

GM Hirschfield, MB Pepys - Qjm, 2003 - academic.oup.com
The classical acute-phase protein, C-reactive protein (CRP), is an exquisitely sensitive
systemic marker of disease with broad clinical utility for monitoring and differential diagnosis …

C-reactive protein is a mediator of cardiovascular disease

RJ Bisoendial, SM Boekholdt, M Vergeer… - European heart …, 2010 - academic.oup.com
C-reactive protein is postulated to embody an index that can reflect cardiovascular risk and
can be used to independently predict major cardiovascular events and mortality. On the …

Contrasting Actions of Endothelin ETA and ETB Receptors in Cardiovascular Disease

MP Schneider, EI Boesen… - Annu. Rev. Pharmacol …, 2007 - annualreviews.org
First identified as a powerful vasoconstrictor, endothelin has an extremely diverse set of
actions that influence homeostatic mechanisms throughout the body. Two receptor subtypes …

Systemic inflammation in patients with COPD and pulmonary hypertension

P Joppa, D Petrasova, B Stancak, R Tkacova - Chest, 2006 - Elsevier
Study objectives COPD is a systemic disorder that is associated with increases of
inflammatory proteins in systemic circulation. However, no data on the potential role of …

Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease

DD Sin, P Lacy, E York, SFP Man - American journal of respiratory …, 2004 - atsjournals.org
Systemic inflammation is present in chronic obstructive pulmonary disease (COPD), which
has been linked to cardiovascular morbidity and mortality. We determined the effects of oral …