Splenectomy is an effective therapy for steroid-refractory or dependent immune
thrombocytopenia (ITP). With the advent of medical alternatives such as rituximab and …

Progressive multifocal leukoencephalopathy (PML) is a rare, devastating demyelinating
disease of the CNS caused by the JC virus (JCV) that occurs in patients with compromised …

Immunomodulatory and immunosuppressive treatments for multiple sclerosis (MS) are
associated with an increased risk of infection, which makes treatment of this condition …

Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

The clinical success of anti-CD20 monoclonal antibody (mAb)-mediated B cell depletion
therapy has contributed to the understanding of B cells as major players in several …

Purpose New treatments are needed for patients with fludarabine-and alemtuzumab-
refractory (FA-ref) chronic lymphocytic leukemia (CLL) or patients with fludarabine-refractory …

Background Since initial approval for the treatment of rheumatoid arthritis (RA), rituximab
has been evaluated in clinical trials involving various populations with RA. Information has …

Neurotoxicity caused by traditional chemotherapy and radiotherapy is widely recognized in
patients with cancer. The adverse effects of newer therapeutics, such as biological and …

Results Patients in the intervention group showed significantly lower infection-associated
(rate difference, 0.7 episodes/patient per year; 95% confidence intervals [CI] 0.3, 1.1) and …

Autoimmune hemolytic anemia is a heterogeneous disease with respect to the type of the
antibody involved and the absence or presence of an underlying condition. Treatment …