DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.
Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …
development, although existing evidence for this varies. We present a meta-analysis and …
Mechanisms linking childhood trauma exposure and psychopathology: A transdiagnostic model of risk and resilience
Background Transdiagnostic processes confer risk for multiple types of psychopathology
and explain the co-occurrence of different disorders. For this reason, transdiagnostic …
and explain the co-occurrence of different disorders. For this reason, transdiagnostic …
Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents
Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …
development, which may contribute to poor mental and physical health outcomes. Evidence …
Early adversity and development: parsing heterogeneity and identifying pathways of risk and resilience
DG Gee - American Journal of Psychiatry, 2021 - Am Psychiatric Assoc
Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …
Delineating the neurodevelopmental pathways by which early adversity affects mental …
Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …
patterns that may be related to psychiatric risk. However, few studies have investigated …
A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches
Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …
health problems across the lifespan. Increasing evidence supports the hypothesis that …
Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care
A growing body of evidence indicates that patients with cancer who receive cytotoxic
treatments (such as chemotherapy or radiotherapy) have an increased risk of accelerated …
treatments (such as chemotherapy or radiotherapy) have an increased risk of accelerated …
Traumatic stress and accelerated DNA methylation age: a meta-analysis
Background Recent studies examining the association between posttraumatic stress
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …
turn has been shown to predict numerous physical and mental health problems. In recent …