Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but
glutamate has since been shown to regulate neurogenesis, neurite outgrowth …

Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Objective: To pool data from completed amyotrophic lateral sclerosis (ALS) clinical trials and
create an open-access resource that enables greater understanding of the phenotype and …

Amyotrophic lateral sclerosis (known in the UK as motor neuron disease) is a devastating
illness with uncertain pathogenesis. In this Seminar, we review its natural history, clinical …

Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and
disability worldwide with impairments ranging from mild to severe. Many therapies are …

The biomedical literature on the subject of neurotrophic growth factors has expanded
prodigiously. This essay reviews neurotrophic factors (NTF) and their receptors in …

Background Both positive and negative associations between higher body mass index (BMI)
and Parkinson disease (PD) have been reported in observational studies, but it has been …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons, and have since been shown to control a …