The tripartite motif containing (TRIM) proteins are a family of proteins that have been
implicated in many biological processes including cell differentiation, apoptosis …

The transient delivery of gene products (RNA or proteins) is not a biotechnological invention
but rather an evolutionarily conserved process underlying and regulating a variety of …

Mobile genetic elements have significantly shaped our genomic landscape. LINE-1
retroelements are the only autonomously active elements left in the human genome. Since …

HIV-exposed seronegative individuals (HESIs) are a small fraction of persons who are
multiply exposed to human immunodeficiency virus (HIV), but do not exhibit serological or …

ABSTRACT TRIM5α is a restriction factor that can block an early step in the retroviral life
cycle by recognizing and causing the disassembly of incoming viral capsids, thereby …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic
zoonotic virus that spreads rapidly. In this work, we improve the hitherto existing …

Background Bovine leukemia virus (BLV) infection is omnipresent in dairy herds causing
direct economic losses due to trade restrictions and lymphosarcoma-related deaths. Milk …

Background HIV-1 replication depends on a delicate balance between cellular co-factors
and antiviral restriction factors. Lens epithelium-derived growth factor (LEDGF/p75) benefits …

Infections with HIV represent a great challenge for the development of strategies for an
effective cure. The spectrum of diseases associated with HIV ranges from opportunistic …

Human immunodeficiency virus (HIV) has a very narrow host range. HIV type 1 (HIV-1) does
not infect Old World monkeys, such as the rhesus monkey (Rh). Rh TRIM5α was identified …