The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

Simple Summary The ubiquitin-proteasome system regulates multiple facets of protein
homeostasis to modulate signal transduction in numerous biological processes. Not …

Breast cancer has the highest incidence and death rate among cancers in women
worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and …

Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

Simple Summary The ubiquitin proteasome system (UPS) governs the non-lysosomal
degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. Dysregulation …

Cancer is a comprehensive classification encompassing more than 100 forms of
malignancies that manifest in diverse tissues within the human body. Recent studies have …

Post-translational modifications (PTMs) are a covalent processing process of proteins after
translation. Proteins are capable of playing their roles only after being modified, so as to …