Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA
polymerase and subsequent transcription initiation. Bacterial cells are able to tune their …

Protein aggregation occurs as a consequence of perturbations in protein homeostasis that
can be triggered by environmental and cellular stresses. The accumulation of protein …

The fundamental details of how nutritional stress leads to elevating (p) ppGpp are
questionable. By common usage, the meaning of the stringent response has evolved from …

During stress, bacteria undergo extensive physiological transformations, many of which are
coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by …

Bacteria use their genetic material with great effectiveness to make the right products in the
correct amounts at the appropriate time. Studying bacterial transcription initiation in …

For an organism to survive, it must be able to sense its environment and regulate
physiological processes accordingly. Understanding how bacteria integrate signals from …

Conditions that sustain constant bacterial growth are seldom found in nature. Oligotrophic
environments and competition among microorganisms force bacteria to be able to adapt …

▪ Abstract Promoter recognition in eubacteria is carried out by the initiation factor sigma,
which binds RNA polymerase and initiates transcription. Cells have one housekeeping …

▪ Abstract Certain strains of fluorescent pseudomonads are important biological components
of agricultural soils that are suppressive to diseases caused by pathogenic fungi on crop …

Although toxin–antitoxin gene cassettes were first found in plasmids, recent database
mining has shown that these loci are abundant in free-living prokaryotes, including many …