BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction

D Qin, XF Jia, A Hanna, J Lee, R Pekson… - Journal of Molecular and …, 2023 - Elsevier
At least seven cell death programs are activated during myocardial infarction (MI), but which
are most important in causing heart damage is not understood. Two of these programs are …

The systemic deletion of interleukin-1α reduces myocardial inflammation and attenuates ventricular remodeling in murine myocardial infarction

J Lugrin, R Parapanov, G Milano, S Cavin… - Scientific Reports, 2023 - nature.com
Myocardial inflammation following myocardial infarction (MI) is crucial for proper myocardial
healing, yet, dysregulated inflammation may promote adverse ventricular remodeling and …

Standardisation and future of preclinical echocardiography

CE O'Riordan, P Trochet, M Steiner, D Fuchs - Mammalian Genome, 2023 - Springer
Echocardiography is a non-invasive imaging technique providing real-time information to
assess the structure and function of the heart. Due to advancements in technology, ultra …

[HTML][HTML] Localized strain characterization of cardiomyopathy in Duchenne muscular dystrophy using novel 4D kinematic analysis of cine cardiovascular magnetic …

CC Earl, VI Pyle, SQ Clark, K Annamalai… - Journal of …, 2023 - Elsevier
Background Cardiomyopathy (CMP) is the most common cause of mortality in Duchenne
muscular dystrophy (DMD), though the age of onset and clinical progression vary. We …

Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with heart–brain dysfunctions in adulthood

K Leyba, N Paiyabhroma, JP Salvas… - Acta …, 2023 - Wiley Online Library
Aim Retrospective studies suggest that mild traumatic brain injury (mTBI) in pediatric
patients may lead to an increased risk of cardiac events. However, the exact functional and …

[HTML][HTML] PPARγ Agonist Pioglitazone Prevents Hypoxia-induced Cardiac Dysfunction by Reprogramming Glucose Metabolism

Y Wang, R Zhang, Q Chen, Z Lei, C Shi… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
The heart relies on various defense mechanisms, including metabolic plasticity, to maintain
its normal structure and function under high-altitude hypoxia. Pioglitazone, a peroxisome …

[HTML][HTML] Postnatally overfed mice display cardiac function alteration following myocardial infarction

M Josse, E Rigal, N Rosenblatt-Velin, B Collin… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background Cardiovascular (CV) pathologies remain a leading cause of death worldwide,
often associated with common comorbidities such as overweight, obesity, type 2 diabetes or …

4D ultrasound‐based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction

ACM Omoto, CC Earl, AM Richards… - Physiological …, 2024 - Wiley Online Library
Abstract Two‐dimensional ultrasound (2DUS) echocardiography is the main noninvasive
method used to evaluate cardiac function in animal models of myocardial infarction (MI) …

High-resolution cardiac positron emission tomography/computed tomography for small animals

D Panetta, MA Guzzardi, F La Rosa… - JoVE (Journal of …, 2022 - jove.com
Positron emission tomography (PET) and computed tomography (CT) are among the most
employed diagnostic imaging techniques, and both serve in understanding cardiac function …

[HTML][HTML] Functional cardiac consequences of β-adrenergic stress-induced injury in the mdx mouse model of Duchenne muscular dystrophy

CC Earl, AJ Javier, AM Richards, LW Markham… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD),
however, in the mdx mouse model of DMD, the cardiac phenotype differs from that seen in …