Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Agonists activating β2-adrenoceptors (β2ARs) on airway smooth muscle (ASM) are the drug
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …

The airway epithelial cell is the initial cell type impacted both by inhaled environmental
factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway …

Chronic degenerative inflammatory diseases, such as chronic obstructive pulmonary
disease and Alzheimer's dementia, afflict millions of people around the world, causing death …

Монография посвящена важной проблеме пульмонологии–роли измененной
реактивности дыхательных путей в формировании, прогрессировании …

Addition of an inhaled long-acting β2-adrenoceptor agonist (LABA) to an inhaled
corticosteroid (ICS) is more effective at improving asthma control and reducing …

Glucocorticoids are widely used to treat various inflammatory lung diseases. Acting via the
glucocorticoid receptor (GR), they exert clinical effects predominantly by modulating gene …

There is unequivocal evidence that the combination of an inhaled corticosteroid (ICS)—ie
glucocorticoid—and an inhaled long‐acting β2‐adrenoceptor agonist (LABA) is superior to …

Background Epidemiological evidence has suggested a link between beta‐agonists and
increases in asthma mortality. There has been much debate about possible causal links for …

The airway smooth muscle (ASM) plays an indispensable role in airway structure and
function. Dysfunction in ASM plays a central role in the pathogenesis of chronic obstructive …