N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it
acts as a neuromodulator of glutamatergic synapses by activating presynaptic metabotropic …

The pathological condition of insulin resistance prevents the neuroprotective effects of
insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk …

Salvianolic acid C (SAC) is a major bioactive component of Salvia miltiorrhiza Bunge
(Danshen), a Chinese herb for treating ischemic stroke (IS). However, the mechanism by …

We have previously shown that a fatty acid-binding protein7 (FABP7) inhibitor ameliorates
cerebral ischemia-reperfusion injury in mice, suggesting an association between FABPs and …

Cerebral stroke is a common neurological disease and often causes severe neurological
deficits. With high morbidity, mortality, and disability rates, stroke threatens patients' life …

A major challenge for the efficient treatment of traumatic brain injury is the need for
therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain …

Evidence from clinical studies and preclinical studies supports that exercise preconditioning
can not only reduce the risk of stroke but also improve brain tissue and functional outcome …

Ischemic stroke has been a prominent focus of scientific investigation owing to its high
prevalence, complex pathogenesis, and difficulties in treatment. Mitochondria play an …

Ischemic stroke is the leading cause of death and long-term disability worldwide, and, while
considerable progress has been made in understanding its pathophysiology, the lack of …

Abstract Dl-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.
However, the precise underlying mechanism requires further investigation. In this study, we …