Comprehensive characterization of phytochemicals and biological activities of the Italian ancient apple 'Mela Rosa dei Monti Sibillini'

JGN Wandjou, L Lancioni, MC Barbalace… - Food research …, 2020 - Elsevier
This study was carried out to characterize extracts from nine samples of the apple 'Mela
Rosa dei Monti Sibillini'(MR) and to assess the antioxidant and anti-inflammatory activities …

Phloretin improves ultrafiltration and reduces glucose absorption during peritoneal dialysis in rats

K Bergling, G Martus, CM Öberg - Journal of the American Society …, 2022 - journals.lww.com
Background Harmful glucose exposure and absorption remain major limitations of
peritoneal dialysis (PD). We previously showed that inhibition of sodium glucose …

Chalcone: A valuable scaffold upgrading by green methods

GP Rosa, AML Seca, MC Barreto… - ACS Sustainable …, 2017 - ACS Publications
Chalcones are naturally occurring α, β-unsaturated carbonyl compounds owning a wide
range of pharmaceutical and industrial applications. They are also key precursors in the …

Metabolome and transcriptome signatures shed light on the anti-obesity effect of Polygonatum sibiricum

X Ou, X Wang, B Zhao, Y Zhao, H Liu… - Frontiers in Plant …, 2023 - frontiersin.org
Obesity has become one of the major threats to human health across the globe. The
rhizomes of Polygonatum sibiricum have shown promising anti-obesity effect. However, the …

Polymorphism and distinct physicochemical properties of the phloretin–nicotinamide cocrystal

S Aitipamula, LP Shan, KM Gupta - CrystEngComm, 2022 - pubs.rsc.org
The emergence of cocrystals as alternative solid forms for development of novel drug
products signifies the relevance of polymorphism studies in cocrystals. We report two novel …

Targeting ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: Lessons learned from clinical trials

SF Nabavi, AG Atanasov, H Khan, D Barreca… - Cancer letters, 2018 - Elsevier
The ubiquitin-proteasome pathway (UPP) is the main non-lysosomal proteolytic system
responsible for degradation of most intracellular proteins, specifically damaged and …

A molecular dynamics perspective into estrogen receptor inhibition by selective flavonoids as alternative therapeutic options

A Sinyani, K Idowu, L Shunmugam… - Journal of …, 2023 - Taylor & Francis
Zearalenone is an estrogenic mycotoxin which is a common food contaminant and has been
implicated in increasing the incidence of carcinogenesis and other reproductive health …

Encapsulation of Phloretin in a ternary Nanocomplex prepared with Phytoglycogen–Caseinate–pectin via electrostatic interactions and chemical cross-linking

Y Chen, J Xue, Y Luo - Journal of Agricultural and Food Chemistry, 2020 - ACS Publications
In this study, we chemically modified a phytoglycogen structure to introduce negative surface
charge via carboxymethylation (CMPG) and then prepared CMPG-based ternary …

Assessment of human inter-individual variability of phloretin metabolites in urine after apple consumption. AppleCOR study

A Macià, MP Romero, A Pedret, R Solà, MN Clifford… - Food & Function, 2023 - pubs.rsc.org
Purpose: This study aimed to assess the inter-individual variation in phloretin absorption
and metabolism and to seek possible phloretin metabotypes following apple snack …

Synthesis of biobased phloretin analogues: An access to antioxidant and anti-tyrosinase compounds for cosmetic applications

L Minsat, C Peyrot, F Brunissen, JH Renault, F Allais - Antioxidants, 2021 - mdpi.com
The current cosmetic and nutraceutical markets are characterized by a strong consumer
demand for a return to natural products that are less harmful to both the consumers and the …