Global population increases and climate change pose a challenge to worldwide crop
production. There is a need to intensify agricultural production in a sustainable manner and …

Microbial cells operate under governing constraints that limit their range of possible
functions. With the availability of annotated genome sequences, it has become possible to …

The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …

Network reconstructions are a common denominator in systems biology. Bottom–up
metabolic network reconstructions have been developed over the last 10 years. These …

An important goal of whole-cell computational modeling is to integrate detailed biochemical
information with biological intuition to produce testable predictions. Based on the premise …

Abstract Flux Balance Analysis (FBA) has been used in the past to analyze microbial
metabolic networks. Typically, FBA is used to study the metabolic flux at a particular steady …

Biology is going through a paradigm shift from reductionist to holistic, systems-based
approaches. The complete genome sequence for a number of organisms is available and …

Annotated genome sequences, can be used to reconstruct whole-cell metabolic networks,,,.
These metabolic networks can be modelled and analysed (computed) to study complex …

A significant goal in the post-genome era is to relate the annotated genome sequence to the
physiological functions of a cell. Working from the annotated genome sequence, as well as …

Computational procedures for predicting metabolic interventions leading to the
overproduction of biochemicals in microbial strains are widely in use. However, these …