In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Capsaicin is a unique alkaloid found primarily in the fruit of the Capsicum genus and is what
provides its spicy flavor. Generally extracted directly from fruit, high demand has driven the …

Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …

With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

A wide variety of phytochemicals are consumed for their perceived health benefits. Many of
these phytochemicals have been found to alter numerous cell functions, but the mechanisms …

Curcumin is the active ingredient of turmeric powder, a natural spice used for generations in
traditional medicines. Curcumin's broad spectrum of antioxidant, anticarcinogenic …

Capsaicin (CAP) is a spice-derived substance of the genus Capsicum, which has high
pungency and therapeutic potential. For many years, it has been considered only as an …

The effect of a pungent ingredient of red pepper, capsaicin, on lipid peroxidation of rat liver
mitochondria (RLM) induced by ADP/Fe2+ was studied. Capsaicin inhibited the lipid …

At submicromolar concentrations, capsaicin specifically activates the TRPV1 receptor
involved in nociception. At micro-to millimolar concentrations, commonly used in clinical and …

In spite of the rapid advances in our understanding of vanilloid-receptor pharmacology in the
PNS, the function of vanilloid receptors in the brain has remained elusive. Recently, the …