Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Skeletal muscle mass is, in part, regulated by the rate of mRNA translation (ie, protein
synthesis). The conserved serine/threonine kinase, mTOR (the mammalian/mechanistic …

Sheep is a major contributor to global food production among livestock and one of the great
sources of red meat for human consumption. Several QTL and numerous genes with major …

The Warburg effect links growth and glycolysis in cancer. A key purpose of the Warburg
effect is to generate glycolytic intermediates for anabolic reactions, such as nucleotides→ …

The ability to genetically manipulate mice allows for gain-and loss-of-function in vivo,
making them an ideal model for elucidating mechanisms of skeletal muscle mass regulation …

Although transcriptome profiling has been used in several resistance training studies, the
associated analytical approaches seldom provide in-depth information on individual genes …