[HTML][HTML] Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Flavonoids target human herpesviruses that infect the nervous system: Mechanisms of action and therapeutic insights

M Šudomová, K Berchová-Bímová, A Mazurakova… - Viruses, 2022 - mdpi.com
Human herpesviruses (HHVs) are large DNA viruses with highly infectious characteristics.
HHVs can induce lytic and latent infections in their host, and most of these viruses are …

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?

A Majewska, B Mlynarczyk-Bonikowska - International journal of …, 2022 - mdpi.com
Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …

ChAdOx1‐S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination

M Cokarić Brdovčak, J Materljan… - European Journal of …, 2022 - Wiley Online Library
COVID‐19 vaccines prevent severe forms of the disease, but do not warrant complete
protection against breakthrough infections. This could be due to suboptimal mucosal …

Chitosan/benzyloxy-benzaldehyde modified ZnO nano template having optimized and distinct antiviral potency to human cytomegalovirus

B Jana, A Chatterjee, D Roy, S Ghorai, D Pan… - Carbohydrate …, 2022 - Elsevier
Utilization of biomolecules encapsulated nano particles is currently originating ample
attention to generate unconventional nanomedicines in antiviral research. Zinc oxide …

Well Put Together—A Guide to Accessorizing with the Herpesvirus gH/gL Complexes

GL Gonzalez-Del Pino, EE Heldwein - Viruses, 2022 - mdpi.com
Herpesviruses are enveloped, double-stranded DNA viruses that infect a variety of hosts
across the animal kingdom. Nine of these establish lifelong infections in humans, for which …

Emerging concepts in congenital cytomegalovirus

MH Pesch, MR Schleiss - Pediatrics, 2022 - publications.aap.org
Over a century of research has focused on improving our understanding of congenital
cytomegalovirus (cCMV), yet it remains the most common congenital infection in the United …

[HTML][HTML] Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes

BM Spector, M Parida, M Li, CB Ball, JL Meier… - Nature …, 2022 - nature.com
Interactions of the RNA polymerase II (Pol II) preinitiation complex (PIC) and paused early
elongation complexes with the first downstream (+ 1) nucleosome are thought to be …

[HTML][HTML] The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

AC Gomes, IA Baraniak, A Lankina, Z Moulder… - Nature …, 2023 - nature.com
Vaccination against human cytomegalovirus (CMV) infection remains high priority. A
recombinant form of a protein essential for CMV entry, glycoprotein B (gB), demonstrated …

Roles of infection in psoriasis

S Zhou, Z Yao - International Journal of Molecular Sciences, 2022 - mdpi.com
Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic
manifestations. Genetic predisposition, environmental factors, and immune dysfunction all …