Targeted protein degradation (TPD) has been established as a viable alternative to
attenuate the function of a specific protein of interest in both biological and clinical contexts …

In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

Aging is a key independent risk factor of various vascular diseases, for which the regulatory
mechanisms remain largely unknown. Bromodomain-containing protein 4 (BRD4) is a …

Histone demethylation is a kind of epigenetic modification mediated by a variety of enzymes
and participates in regulating multiple physiological and pathological events. Lysine-specific …

Protein O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) plays a crucial role
in regulating essential cellular processes. The disruption of the homeostasis of O …

As a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain-
containing protein 4) is a chromatin-associated protein that interacts with acetylated histones …

The ubiquitin-proteasome system (UPS) governs the degradation of proteins by
ubiquitinating their lysine residues. Our study focuses on lysine deserts-regions in proteins …

Summary Bromodomain-containing protein 4 (BRD4) has emerged as a promising
therapeutic target in prostate cancer (PCa). Understanding the mechanisms of BRD4 …

Colorectal cancer (CRC) is one of the most common cancers worldwide. Its main modifiable
risk factors are diet, alcohol consumption, and smoking. Thus, the right approach through …

Formerly hailed as “undruggable” proteins, transcription factors (TFs) are now under
investigation for targeted therapy. In cancer, this may alter, inter alia, immune evasion or …