Protein kinases: drug targets for immunological disorders
L Castelo-Soccio, H Kim, M Gadina… - Nature Reviews …, 2023 - nature.com
Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …
Alopecia areata: Current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines
M Fukuyama, T Ito, M Ohyama - The Journal of dermatology, 2022 - Wiley Online Library
Alopecia areata (AA) is a relatively common nonscarring hairloss disease characterized by
an autoimmune response to anagen hair follicles (HFs). Accumulated evidence suggests …
an autoimmune response to anagen hair follicles (HFs). Accumulated evidence suggests …
Dupilumab in inflammatory skin diseases: a systematic review
Dupilumab was first approved for the treatment of atopic dermatitis (AD) and blocks the
signaling of interleukin (IL)-4 and-13. Several other chronic skin conditions share …
signaling of interleukin (IL)-4 and-13. Several other chronic skin conditions share …
Alopecia areata: current treatments and new directions
Alopecia areata is an autoimmune hair loss disease that is non-scarring and is
characterized by chronic inflammation at the hair follicle level. Clinically, patients' …
characterized by chronic inflammation at the hair follicle level. Clinically, patients' …
Is atopic dermatitis only a skin disease?
A Mesjasz, M Zawadzka, M Chałubiński… - International Journal of …, 2023 - mdpi.com
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant
patient and population burdens. In addition to the cutaneous signs and symptoms, growing …
patient and population burdens. In addition to the cutaneous signs and symptoms, growing …
Association of atopic dermatitis with autoimmune diseases: A bidirectional and multivariable two-sample mendelian randomization study
W Zhou, J Cai, Z Li, Y Lin - Frontiers in Immunology, 2023 - frontiersin.org
Background Observational studies have suggested the association between atopic
dermatitis (AD) and the risks of autoimmune diseases. It is still unclear, however, whether or …
dermatitis (AD) and the risks of autoimmune diseases. It is still unclear, however, whether or …
[HTML][HTML] Upadacitinib improved alopecia areata in a patient with atopic dermatitis: a case report
M Cantelli, F Martora, C Patruno, P Nappa… - Dermatologic …, 2022 - ncbi.nlm.nih.gov
Dear Editor, Atopic dermatitis (AD) and alopecia areata (AA) are two common diseases that
can coexist in the same patient, sharing some pathogenetic aspects such as the …
can coexist in the same patient, sharing some pathogenetic aspects such as the …
Scalp biomarkers during dupilumab treatment support Th2 pathway pathogenicity in alopecia areata
Y Renert‐Yuval, AB Pavel, E Del Duca, P Facheris… - Allergy, 2023 - Wiley Online Library
Background The mechanisms driving alopecia areata (AA) are still unclear, hindering
development of targeted therapeutics. Specific Th2 targeting with dupilumab in AA provides …
development of targeted therapeutics. Specific Th2 targeting with dupilumab in AA provides …
Comorbid conditions associated with alopecia areata: a systematic review and meta-analysis
Background Alopecia areata (AA) is a complex autoimmune condition resulting in
nonscarring hair loss. In recent years, many studies have provided new evidence on …
nonscarring hair loss. In recent years, many studies have provided new evidence on …
Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors
AK Gupta, T Wang, S Polla Ravi… - Journal of the …, 2023 - Wiley Online Library
Management options for moderate‐to‐severe alopecia areata (AA) are limited owing to a
lack of safe and effective treatments suitable for long‐term use. However, newer agents …
lack of safe and effective treatments suitable for long‐term use. However, newer agents …