Biofilms: formation, research models, potential targets, and methods for prevention and treatment

Y Su, JT Yrastorza, M Matis, J Cusick, S Zhao… - Advanced …, 2022 - Wiley Online Library
Due to the continuous rise in biofilm‐related infections, biofilms seriously threaten human
health. The formation of biofilms makes conventional antibiotics ineffective and dampens …

The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

M Malone, T Bjarnsholt, AJ McBain… - Journal of wound …, 2017 - magonlinelibrary.com
The presence of biofilms in chronic non-healing wounds, has been identified through in vitro
model and in vivo animal data. However, human chronic wound studies are under …

Microbial species isolated from infected wounds and antimicrobial resistance analysis: Data emerging from a three-years retrospective study

V Puca, RZ Marulli, R Grande, I Vitale, A Niro… - Antibiotics, 2021 - mdpi.com
The antimicrobial resistance is a topic of global interest in the treatment of wound infections.
The goal of this retrospective study was both the identification of the microorganisms …

Biofilms in diabetic foot ulcers: significance and clinical relevance

C Pouget, C Dunyach-Remy, A Pantel, S Schuldiner… - Microorganisms, 2020 - mdpi.com
Foot infections are the main disabling complication in patients with diabetes mellitus. These
infections can lead to lower-limb amputation, increasing mortality and decreasing the quality …

Biofilms and wounds: an overview of the evidence

SL Percival, SM McCarty, B Lipsky - Advances in wound care, 2015 - liebertpub.com
Significance: Microorganisms can exist both in the planktonic and biofilm state. Each
phenotypic state has a role to play in delaying healing and causing infections of both acute …

A Guanosine‐Quadruplex Hydrogel as Cascade Reaction Container Consuming Endogenous Glucose for Infected Wound Treatment—A Study in Diabetic Mice

Y Li, L Su, Y Zhang, Y Liu, F Huang, Y Ren… - Advanced …, 2022 - Wiley Online Library
Diabetic foot ulcers infected with antibiotic‐resistant bacteria form a severe complication of
diabetes. Antimicrobial‐loaded hydrogels are used as a dressing for infected wounds, but …

Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Biofilm delays wound healing: a review of the evidence

DG Metcalf, PG Bowler - Burns & trauma, 2013 - academic.oup.com
Biofilm is the predominant mode of life for bacteria and today it is implicated in numerous
human diseases. A growing body of scientific and clinical evidence now exists regarding the …

Eradication of Multidrug‐Resistant Staphylococcal Infections by Light‐Activatable Micellar Nanocarriers in a Murine Model

Y Liu, HC van der Mei, B Zhao, Y Zhai… - Advanced Functional …, 2017 - Wiley Online Library
Bacterial infections are mostly due to bacteria in their biofilm mode‐of‐growth, making them
recalcitrant to antibiotic penetration. In addition, the number of bacterial strains intrinsically …

Importance of biofilm formation in surgical infection

SL Percival - Journal of British Surgery, 2017 - academic.oup.com
Background Biofilms are ubiquitous, and have been observed in both acute and chronic
wounds. Their role in wound healing and infection, however, remains controversial. The aim …